Preheat oven to 350°F. Line a 13x18-inch rimmed baking sheet with parchment paper (leave the parchment slightly higher than the sides of the pan so it's easy to lift the cake out after). Lightly spray the parchment paper with nonstick spray and set aside.
In a medium bowl, whisk the flour, strawberry Jell-O powder, baking powder, baking soda, and salt together. Set aside.
2½ cups all-purpose flour, 2 tablespoons strawberry Jell-O powder, 2 teaspoons baking powder, 1 teaspoon baking soda, ½ teaspoon kosher salt
In a separate large bowl, use a hand mixer to beat (on high speed) the butter and granulated sugar together until well combined and lighter in color, about 2 minutes. Use a spatula to scrape down sides of bowl.
¾ cup unsalted butter, 1½ cups granulated sugar
Add the eggs and vanilla into the butter mixture and beat on high until the mixture is fluffy and well mixed, about 1 minute. Use a spatula to scrape down the sides of the bowl to make sure all ingredients are combined properly.
3 large eggs, 1 teaspoon pure vanilla extract
On low speed, beat the milk into the butter mixture until combined, about 30 seconds. The mixture may look a bit curdled but that’s perfectly normal.
½ cup whole milk
On low speed, beat the dry ingredients into the cake batter just until combined (using a spatula to scrape down the sides and bottom of the bowl). Be careful not to overmix this or the cake will not rise properly and it will have a gummy-type texture when baked. Beat just until you no longer see white streaks of flour or large lumps of dry ingredients in the batter. This will take about 30 seconds.
Gently stir (not beat) the strawberry reduction into the cake batter.
½ cup strawberry reduction
Pour the batter onto the prepared sheet cake pan and use a spatula to evenly distribute the cake batter in the pan.
Bake in the preheated oven for 26-27 minutes, or until a toothpick inserted in the middle comes out clean.
Remove cake from oven and let cool completely before frosting.